Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging

Skeletal aging results in apoptosis of osteocytes, cells embedded in bone that control the generation/function of bone forming and resorbing cells. Aging also decreases connexin43 (Cx43) expression in bone; and osteocytic Cx43 deletion partially mimics the skeletal phenotype of old mice. Particularl...

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Detalles Bibliográficos
Autores principales: Davis, Hannah M., Pacheco‐Costa, Rafael, Atkinson, Emily G., Brun, Lucas R., Gortazar, Arancha R., Harris, Julia, Hiasa, Masahiro, Bolarinwa, Surajudeen A., Yoneda, Toshiyuki, Ivan, Mircea, Bruzzaniti, Angela, Bellido, Teresita, Plotkin, Lilian I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418188/
https://www.ncbi.nlm.nih.gov/pubmed/28317237
http://dx.doi.org/10.1111/acel.12586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418188/
https://www.ncbi.nlm.nih.gov/pubmed/28317237
http://dx.doi.org/10.1111/acel.12586

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