Residual Cdk1/2 activity after DNA damage promotes senescence

In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. By studying single cells, we show that Cdk activity persists after DNA damage...

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Detalles Bibliográficos
Autores principales: Müllers, Erik, Silva Cascales, Helena, Burdova, Kamila, Macurek, Libor, Lindqvist, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418196/
https://www.ncbi.nlm.nih.gov/pubmed/28345297
http://dx.doi.org/10.1111/acel.12588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418196/
https://www.ncbi.nlm.nih.gov/pubmed/28345297
http://dx.doi.org/10.1111/acel.12588

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