Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism

Senescent cells contribute to age‐related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to d...

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Detalles Bibliográficos
Autores principales: Wang, Rong, Yu, Zhen, Sunchu, Bharath, Shoaf, James, Dang, Ivana, Zhao, Stephanie, Caples, Kelsey, Bradley, Lynda, Beaver, Laura M., Ho, Emily, Löhr, Christiane V., Perez, Viviana I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418203/
https://www.ncbi.nlm.nih.gov/pubmed/28371119
http://dx.doi.org/10.1111/acel.12587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418203/
https://www.ncbi.nlm.nih.gov/pubmed/28371119
http://dx.doi.org/10.1111/acel.12587

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