Cargando…

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism

Senescent cells contribute to age‐related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Rong, Yu, Zhen, Sunchu, Bharath, Shoaf, James, Dang, Ivana, Zhao, Stephanie, Caples, Kelsey, Bradley, Lynda, Beaver, Laura M., Ho, Emily, Löhr, Christiane V., Perez, Viviana I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418203/ https://www.ncbi.nlm.nih.gov/pubmed/28371119 http://dx.doi.org/10.1111/acel.12587

Ejemplares similares

Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction
por: Yu, Zhen, et al.
Publicado: (2015)

Quantitative Proteomic Analysis of the Senescence‐Associated Secretory Phenotype by Data‐Independent Acquisition
por: Neri, Francesco, et al.
Publicado: (2021)

Cell senescence, the senescence-associated secretory phenotype, and cancers
por: Langhi Prata, Larissa G. P., et al.
Publicado: (2023)

Cellular senescence, senescence-associated secretory phenotype, and chronic kidney disease
por: Wang, Wen-Juan, et al.
Publicado: (2017)

MLL1 is essential for the senescence-associated secretory phenotype
por: Capell, Brian C., et al.
Publicado: (2016)

The Role of Senescence-Associated Secretory Phenotype in Bone Loss
por: Zhu, Runjiu, et al.
Publicado: (2022)

The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation
por: Huna, Anda, et al.
Publicado: (2023)

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
por: Kumari, Ruchi, et al.
Publicado: (2021)

ANTI-CELL SENESCENT EFFECTS OF RAPAMYCIN AND THEIR ROLE IN DISEASES, INCLUDING ALZHEIMER’S
por: Perez, Viviana I
Publicado: (2019)

Senescence-activated enhancer landscape orchestrates the senescence-associated secretory phenotype in murine fibroblasts
por: Guan, Yiting, et al.
Publicado: (2020)

Immunotherapeutic approach to reduce senescent cells and alleviate senescence‐associated secretory phenotype in mice
por: Shrestha, Niraj, et al.
Publicado: (2023)

In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers
por: Samakkarnthai, Parinya, et al.
Publicado: (2023)

NF90 coordinately represses the senescence-associated secretory phenotype
por: Tominaga-Yamanaka, Kumiko, et al.
Publicado: (2012)

HMGB2 holds the key to the senescence-associated secretory phenotype
por: Guerrero, Ana, et al.
Publicado: (2016)

Suppression of p16 alleviates the senescence-associated secretory phenotype
por: Buj, Raquel, et al.
Publicado: (2021)

Rapamycin, proliferation and geroconversion to senescence
por: Blagosklonny, Mikhail V.
Publicado: (2018)

A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence
por: Meyer, Patrick, et al.
Publicado: (2017)

IFN-γ and TNF Induce Senescence and a Distinct Senescence-Associated Secretory Phenotype in Melanoma
por: Homann, Lorenzo, et al.
Publicado: (2022)

Ceria Nanoparticles Alleviated Osteoarthritis through Attenuating Senescence and Senescence-Associated Secretory Phenotype in Synoviocytes
por: Ren, Xunshan, et al.
Publicado: (2023)

Colchicine Protects against Ethanol-Induced Senescence and Senescence-Associated Secretory Phenotype in Endothelial Cells
por: Zhou, Huakang, et al.
Publicado: (2023)

Exosomes as Emerging Pro-Tumorigenic Mediators of the Senescence-Associated Secretory Phenotype
por: Jakhar, Rekha, et al.
Publicado: (2019)

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration
por: Ritschka, Birgit, et al.
Publicado: (2017)

Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma
por: Lee, Jee San, et al.
Publicado: (2017)

The bright and dark side of extracellular vesicles in the senescence-associated secretory phenotype
por: Wallis, Ryan, et al.
Publicado: (2020)

Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
por: Kuehnemann, Chisaka, et al.
Publicado: (2022)

Senescence-associated secretory phenotype and its impact on oral immune homeostasis
por: Yue, Ziqi, et al.
Publicado: (2022)

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
por: Byun, Hae-Ok, et al.
Publicado: (2015)

Impact of senescence‐associated secretory phenotype and its potential as a therapeutic target for senescence‐associated diseases
por: Watanabe, Sugiko, et al.
Publicado: (2017)

Cellular senescence and senescence‐associated secretory phenotype via the cGAS‐STING signaling pathway in cancer
por: Loo, Tze Mun, et al.
Publicado: (2019)

The impact of cellular senescence and senescence‑associated secretory phenotype in cancer‑associated fibroblasts on the malignancy of pancreatic cancer
por: Higashiguchi, Masaya, et al.
Publicado: (2023)

m(6)A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
por: Liu, Pingyu, et al.
Publicado: (2021)

Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation
por: Horvath, Steve, et al.
Publicado: (2019)

Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells
por: Cahu, J, et al.
Publicado: (2012)

Sensitive Detection and Monitoring of Senescence-Associated Secretory Phenotype by SASP-RAP Assay
por: Gu, Liubao, et al.
Publicado: (2012)

Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
por: Wiley, Christopher D., et al.
Publicado: (2018)

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy
por: Saleh, Tareq, et al.
Publicado: (2018)

Senescence-Associated Secretory Phenotype Determines Survival and Therapeutic Response in Cervical Cancer
por: Purohit, Sharad, et al.
Publicado: (2020)

ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytes
por: Niklander, Sven, et al.
Publicado: (2020)

Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer
por: Banerjee, Priyanka, et al.
Publicado: (2021)

Acute ischemic stroke triggers a cellular senescence-associated secretory phenotype
por: Torres-Querol, Coral, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l3v83lq636b2rfh81e5j97d2e9