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Age‐related decline in BubR1 impairs adult hippocampal neurogenesis

Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated an...

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Autores principales: Yang, Zhongxi, Jun, Heechul, Choi, Chan‐II, Yoo, Ki Hyun, Cho, Chang Hoon, Hussaini, Syed Mohammed Qasim, Simmons, Ambrosia J., Kim, Seonhee, van Deursen, Jan M., Baker, Darren J., Jang, Mi‐Hyeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418205/
https://www.ncbi.nlm.nih.gov/pubmed/28383136
http://dx.doi.org/10.1111/acel.12594
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author Yang, Zhongxi
Jun, Heechul
Choi, Chan‐II
Yoo, Ki Hyun
Cho, Chang Hoon
Hussaini, Syed Mohammed Qasim
Simmons, Ambrosia J.
Kim, Seonhee
van Deursen, Jan M.
Baker, Darren J.
Jang, Mi‐Hyeon
author_facet Yang, Zhongxi
Jun, Heechul
Choi, Chan‐II
Yoo, Ki Hyun
Cho, Chang Hoon
Hussaini, Syed Mohammed Qasim
Simmons, Ambrosia J.
Kim, Seonhee
van Deursen, Jan M.
Baker, Darren J.
Jang, Mi‐Hyeon
author_sort Yang, Zhongxi
collection PubMed
description Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated aneuploidy syndrome. Whether BubR1 contributes to age‐related deficits in hippocampal neurogenesis is yet to be determined. Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain. Using established progeroid mice expressing low amounts of BubR1, we demonstrate these mice exhibit deficits in neural progenitor proliferation and maturation, leading to reduction in new neuron production. Collectively, our identification of BubR1 as a new and critical factor controlling sequential steps across neurogenesis raises the possibility that BubR1 may be a key mediator regulating aging‐related hippocampal pathology. Targeting BubR1 may represent a novel therapeutic strategy for age‐related cognitive deficits.
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spelling pubmed-54182052017-06-01 Age‐related decline in BubR1 impairs adult hippocampal neurogenesis Yang, Zhongxi Jun, Heechul Choi, Chan‐II Yoo, Ki Hyun Cho, Chang Hoon Hussaini, Syed Mohammed Qasim Simmons, Ambrosia J. Kim, Seonhee van Deursen, Jan M. Baker, Darren J. Jang, Mi‐Hyeon Aging Cell Short Takes Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated aneuploidy syndrome. Whether BubR1 contributes to age‐related deficits in hippocampal neurogenesis is yet to be determined. Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain. Using established progeroid mice expressing low amounts of BubR1, we demonstrate these mice exhibit deficits in neural progenitor proliferation and maturation, leading to reduction in new neuron production. Collectively, our identification of BubR1 as a new and critical factor controlling sequential steps across neurogenesis raises the possibility that BubR1 may be a key mediator regulating aging‐related hippocampal pathology. Targeting BubR1 may represent a novel therapeutic strategy for age‐related cognitive deficits. John Wiley and Sons Inc. 2017-04-06 2017-06 /pmc/articles/PMC5418205/ /pubmed/28383136 http://dx.doi.org/10.1111/acel.12594 Text en © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Takes
Yang, Zhongxi
Jun, Heechul
Choi, Chan‐II
Yoo, Ki Hyun
Cho, Chang Hoon
Hussaini, Syed Mohammed Qasim
Simmons, Ambrosia J.
Kim, Seonhee
van Deursen, Jan M.
Baker, Darren J.
Jang, Mi‐Hyeon
Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
title Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
title_full Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
title_fullStr Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
title_full_unstemmed Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
title_short Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
title_sort age‐related decline in bubr1 impairs adult hippocampal neurogenesis
topic Short Takes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418205/
https://www.ncbi.nlm.nih.gov/pubmed/28383136
http://dx.doi.org/10.1111/acel.12594
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