Cargando…
Age‐related decline in BubR1 impairs adult hippocampal neurogenesis
Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated an...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418205/ https://www.ncbi.nlm.nih.gov/pubmed/28383136 http://dx.doi.org/10.1111/acel.12594 |
_version_ | 1783234025774645248 |
---|---|
author | Yang, Zhongxi Jun, Heechul Choi, Chan‐II Yoo, Ki Hyun Cho, Chang Hoon Hussaini, Syed Mohammed Qasim Simmons, Ambrosia J. Kim, Seonhee van Deursen, Jan M. Baker, Darren J. Jang, Mi‐Hyeon |
author_facet | Yang, Zhongxi Jun, Heechul Choi, Chan‐II Yoo, Ki Hyun Cho, Chang Hoon Hussaini, Syed Mohammed Qasim Simmons, Ambrosia J. Kim, Seonhee van Deursen, Jan M. Baker, Darren J. Jang, Mi‐Hyeon |
author_sort | Yang, Zhongxi |
collection | PubMed |
description | Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated aneuploidy syndrome. Whether BubR1 contributes to age‐related deficits in hippocampal neurogenesis is yet to be determined. Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain. Using established progeroid mice expressing low amounts of BubR1, we demonstrate these mice exhibit deficits in neural progenitor proliferation and maturation, leading to reduction in new neuron production. Collectively, our identification of BubR1 as a new and critical factor controlling sequential steps across neurogenesis raises the possibility that BubR1 may be a key mediator regulating aging‐related hippocampal pathology. Targeting BubR1 may represent a novel therapeutic strategy for age‐related cognitive deficits. |
format | Online Article Text |
id | pubmed-5418205 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54182052017-06-01 Age‐related decline in BubR1 impairs adult hippocampal neurogenesis Yang, Zhongxi Jun, Heechul Choi, Chan‐II Yoo, Ki Hyun Cho, Chang Hoon Hussaini, Syed Mohammed Qasim Simmons, Ambrosia J. Kim, Seonhee van Deursen, Jan M. Baker, Darren J. Jang, Mi‐Hyeon Aging Cell Short Takes Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated aneuploidy syndrome. Whether BubR1 contributes to age‐related deficits in hippocampal neurogenesis is yet to be determined. Here we report that BubR1 expression is significantly reduced with natural aging in the mouse brain. Using established progeroid mice expressing low amounts of BubR1, we demonstrate these mice exhibit deficits in neural progenitor proliferation and maturation, leading to reduction in new neuron production. Collectively, our identification of BubR1 as a new and critical factor controlling sequential steps across neurogenesis raises the possibility that BubR1 may be a key mediator regulating aging‐related hippocampal pathology. Targeting BubR1 may represent a novel therapeutic strategy for age‐related cognitive deficits. John Wiley and Sons Inc. 2017-04-06 2017-06 /pmc/articles/PMC5418205/ /pubmed/28383136 http://dx.doi.org/10.1111/acel.12594 Text en © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Takes Yang, Zhongxi Jun, Heechul Choi, Chan‐II Yoo, Ki Hyun Cho, Chang Hoon Hussaini, Syed Mohammed Qasim Simmons, Ambrosia J. Kim, Seonhee van Deursen, Jan M. Baker, Darren J. Jang, Mi‐Hyeon Age‐related decline in BubR1 impairs adult hippocampal neurogenesis |
title | Age‐related decline in BubR1 impairs adult hippocampal neurogenesis |
title_full | Age‐related decline in BubR1 impairs adult hippocampal neurogenesis |
title_fullStr | Age‐related decline in BubR1 impairs adult hippocampal neurogenesis |
title_full_unstemmed | Age‐related decline in BubR1 impairs adult hippocampal neurogenesis |
title_short | Age‐related decline in BubR1 impairs adult hippocampal neurogenesis |
title_sort | age‐related decline in bubr1 impairs adult hippocampal neurogenesis |
topic | Short Takes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418205/ https://www.ncbi.nlm.nih.gov/pubmed/28383136 http://dx.doi.org/10.1111/acel.12594 |
work_keys_str_mv | AT yangzhongxi agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT junheechul agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT choichanii agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT yookihyun agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT chochanghoon agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT hussainisyedmohammedqasim agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT simmonsambrosiaj agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT kimseonhee agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT vandeursenjanm agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT bakerdarrenj agerelateddeclineinbubr1impairsadulthippocampalneurogenesis AT jangmihyeon agerelateddeclineinbubr1impairsadulthippocampalneurogenesis |