Cargando…

Age‐related decline in BubR1 impairs adult hippocampal neurogenesis

Aging causes significant declines in adult hippocampal neurogenesis and leads to cognitive disability. Emerging evidence demonstrates that decline in the mitotic checkpoint kinase BubR1 level occurs with natural aging and induces progeroid features in both mice and children with mosaic variegated an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Zhongxi, Jun, Heechul, Choi, Chan‐II, Yoo, Ki Hyun, Cho, Chang Hoon, Hussaini, Syed Mohammed Qasim, Simmons, Ambrosia J., Kim, Seonhee, van Deursen, Jan M., Baker, Darren J., Jang, Mi‐Hyeon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Short Takes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418205/ https://www.ncbi.nlm.nih.gov/pubmed/28383136 http://dx.doi.org/10.1111/acel.12594

Ejemplares similares

sFRP3 inhibition improves age‐related cellular changes in BubR1 progeroid mice
por: Cho, Chang Hoon, et al.
Publicado: (2019)

BubR1 and brain aging
por: Hussaini, Syed Mohammed Qasim, et al.
Publicado: (2017)

The progeroid gene BubR1 regulates axon myelination and motor function
por: Choi, Chan-Il, et al.
Publicado: (2016)

BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice
por: Cho, Chang Hoon, et al.
Publicado: (2018)

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer
por: Weaver, Robbyn L, et al.
Publicado: (2016)

P53 independent pathogenic mechanisms contribute to BubR1 microcephaly
por: Sterling, Noelle A., et al.
Publicado: (2023)

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline
por: Smith, Lucas K., et al.
Publicado: (2020)

Functional Role of Adult Hippocampal Neurogenesis as a Therapeutic Strategy for Mental Disorders
por: Jun, Heechul, et al.
Publicado: (2012)

Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
por: Wijshake, Tobias, et al.
Publicado: (2012)

BubR1 checks in with CENP-E
por: LeBrasseur, Nicole
Publicado: (2003)

BubR1 shows self-control
por: Short, Ben
Publicado: (2012)

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
por: Baker, Darren J., et al.
Publicado: (2012)

A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1
por: Duranteau, Marie, et al.
Publicado: (2016)

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint
por: Zhang, Gang, et al.
Publicado: (2015)

Separating the spindle, checkpoint, and timer functions of BubR1
por: Rahmani, Zohra, et al.
Publicado: (2009)

BUB1 and BUBR1: multifaceted kinases of the cell cycle
por: Bolanos-Garcia, Victor M., et al.
Publicado: (2011)

Coupling of Cdc20 inhibition and activation by BubR1
por: Hein, Jamin B., et al.
Publicado: (2021)

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
por: Mathews, Kathryn J., et al.
Publicado: (2017)

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint
por: Overlack, Katharina, et al.
Publicado: (2015)

BubR1 recruitment to the kinetochore via Bub1 enhances spindle assembly checkpoint signaling
por: Banerjee, Anand, et al.
Publicado: (2022)

BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling
por: Overlack, Katharina, et al.
Publicado: (2017)

Requirement for BUB1B/BUBR1 in tumor progression of lung adenocarcinoma
por: Chen, Honglin, et al.
Publicado: (2015)

Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice
por: Mendias, Christopher L, et al.
Publicado: (2015)

Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity
por: Olova, Nelly, et al.
Publicado: (2018)

Partial Hepatectomy in Acetylation-Deficient BubR1 Mice Corroborates that Chromosome Missegregation Initiates Tumorigenesis
por: Lee, Yoo-Kyung, et al.
Publicado: (2014)

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2015)

Neuronal‐specific proteasome augmentation via Prosβ5 overexpression extends lifespan and reduces age‐related cognitive decline
por: Munkácsy, Erin, et al.
Publicado: (2019)

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit
por: Huang, Haomin, et al.
Publicado: (2008)

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment
por: Zhang, Jiayin, et al.
Publicado: (2007)

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment
por: Zhang, Jiayin, et al.
Publicado: (2007)

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity
por: Tomasini, Richard, et al.
Publicado: (2009)

Haplo-insufficiency of both BubR1 and SGO1 accelerates cellular senescence
por: Park, Sung-Hyun, et al.
Publicado: (2016)

Bub3–BubR1-dependent sequestration of Cdc20(Fizzy) at DNA breaks facilitates the correct segregation of broken chromosomes
por: Derive, Nicolas, et al.
Publicado: (2015)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling
por: Mao, Yinghui, et al.
Publicado: (2005)

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
por: Choi, Eunhee, et al.
Publicado: (2009)

Escaping the firing squad: acetylation of BubR1 protects it from degradation in checkpoint cells
por: Yekezare, Mona, et al.
Publicado: (2009)

CENP-E–dependent BubR1 autophosphorylation enhances chromosome alignment and the mitotic checkpoint
por: Guo, Yige, et al.
Publicado: (2012)

Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells
por: Ikawa-Yoshida, Ayae, et al.
Publicado: (2013)

Infrequent Mutation of the hBUB1 and hBUBR1 Genes in Human Lung Cancer
por: Sato, Mitsuo, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_qi04nku8upnrm9hlnv3enpug87