Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance

Low-grade inflammation links obesity to insulin resistance through the activation of tissue-infiltrating immune cells. Interleukin-6 (IL-6) is a crucial regulator of T cells and is increased in obesity. Here we report that classical IL-6 signalling in T cells promotes inflammation and insulin resist...

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Detalles Bibliográficos
Autores principales: Xu, Elaine, Pereira, Mafalda M. A., Karakasilioti, Ismene, Theurich, Sebastian, Al-Maarri, Mona, Rappl, Gunter, Waisman, Ari, Wunderlich, F. Thomas, Brüning, Jens C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418621/
https://www.ncbi.nlm.nih.gov/pubmed/28466852
http://dx.doi.org/10.1038/ncomms14803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418621/
https://www.ncbi.nlm.nih.gov/pubmed/28466852
http://dx.doi.org/10.1038/ncomms14803

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