Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling

The broad substrate tolerance of tubulin tyrosine ligase is the basic rationale behind its wide applicability for chemoenzymatic protein functionalization. In this context, we report that the wild-type enzyme enables ligation of various unnatural amino acids that are substantially bigger than and st...

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Detalles Bibliográficos
Autores principales: Schumacher, Dominik, Lemke, Oliver, Helma, Jonas, Gerszonowicz, Lena, Waller, Verena, Stoschek, Tina, Durkin, Patrick M., Budisa, Nediljko, Leonhardt, Heinrich, Keller, Bettina G., Hackenberger, Christian P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418632/
https://www.ncbi.nlm.nih.gov/pubmed/28507719
http://dx.doi.org/10.1039/c7sc00574a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418632/
https://www.ncbi.nlm.nih.gov/pubmed/28507719
http://dx.doi.org/10.1039/c7sc00574a

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