Cargando…

A critical examination of the recently reported crystal structures of the human SMN protein

A recent publication by Seng et al. in this journal reports the crystallographic structure of refolded, full-length SMN protein and two disease-relevant derivatives thereof. Here, we would like to suggest that at least two of the structures reported in that study are incorrect. We present evidence t...

Descripción completa

Detalles Bibliográficos
Autores principales: Weiss, Manfred S., Diederichs, Kay, Read, Randy J., Panjikar, Santosh, Van Duyne, Gregory D., Matera, A. Gregory, Fischer, Utz, Grimm, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418738/
https://www.ncbi.nlm.nih.gov/pubmed/27577872
http://dx.doi.org/10.1093/hmg/ddw298