A small molecule p75(NTR) ligand normalizes signalling and reduces Huntington’s disease phenotypes in R6/2 and BACHD mice

Decreases in the ratio of neurotrophic versus neurodegenerative signalling play a critical role in Huntington’s disease (HD) pathogenesis and recent evidence suggests that the p75 neurotrophin receptor (NTR) contributes significantly to disease progression. p75(NTR) signalling intermediates substant...

Descripción completa

Detalles Bibliográficos
Autores principales: Simmons, Danielle A., Belichenko, Nadia P., Ford, Ellen C., Semaan, Sarah, Monbureau, Marie, Aiyaswamy, Sruti, Holman, Cameron M., Condon, Christina, Shamloo, Mehrdad, Massa, Stephen M., Longo, Frank M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418739/
https://www.ncbi.nlm.nih.gov/pubmed/28171570
http://dx.doi.org/10.1093/hmg/ddw316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418739/
https://www.ncbi.nlm.nih.gov/pubmed/28171570
http://dx.doi.org/10.1093/hmg/ddw316

Ejemplares similares