Attenuated pupillary light responses and downregulation of opsin expression parallel decline in circadian disruption in two different mouse models of Huntington’s disease

Circadian deficits in Huntington’s disease (HD) are recapitulated in both fragment (R6/2) and full-length (Q175) mouse models of HD. Circadian rhythms are regulated by the suprachiasmatic nuclei (SCN) in the hypothalamus, which are primarily entrained by light detected by the retina. The SCN receive...

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Detalles Bibliográficos
Autores principales: Ouk, Koliane, Hughes, Steven, Pothecary, Carina A., Peirson, Stuart N., Morton, A. Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418835/
https://www.ncbi.nlm.nih.gov/pubmed/28031289
http://dx.doi.org/10.1093/hmg/ddw359

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418835/
https://www.ncbi.nlm.nih.gov/pubmed/28031289
http://dx.doi.org/10.1093/hmg/ddw359

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