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Specific CDK4/6 inhibition in breast cancer: a systematic review of current clinical evidence
BACKGROUND: Loss of cell cycle control is a hallmark of cancer, and aberrations in the cyclin-dependent kinase-retinoblastoma (CDK-Rb) pathway are common in breast cancer (BC). Consequently, inhibition of this pathway is an attractive therapeutic strategy. The present review addresses efficacy and t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
ESMO Open
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419212/ https://www.ncbi.nlm.nih.gov/pubmed/28848657 http://dx.doi.org/10.1136/esmoopen-2016-000093 |