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Specific CDK4/6 inhibition in breast cancer: a systematic review of current clinical evidence

BACKGROUND: Loss of cell cycle control is a hallmark of cancer, and aberrations in the cyclin-dependent kinase-retinoblastoma (CDK-Rb) pathway are common in breast cancer (BC). Consequently, inhibition of this pathway is an attractive therapeutic strategy. The present review addresses efficacy and t...

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Detalles Bibliográficos
Autores principales: Polk, Anne, Kolmos, Ida Lykke, Kümler, Iben, Nielsen, Dorte Lisbeth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ESMO Open 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419212/
https://www.ncbi.nlm.nih.gov/pubmed/28848657
http://dx.doi.org/10.1136/esmoopen-2016-000093