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Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples
The distribution of fitness effects (DFE) has considerable importance in population genetics. To date, estimates of the DFE come from studies using a small number of individuals. Thus, estimates of the proportion of moderately to strongly deleterious new mutations may be unreliable because such vari...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Genetics Society of America
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419480/ https://www.ncbi.nlm.nih.gov/pubmed/28249985 http://dx.doi.org/10.1534/genetics.116.197145 |