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Inference of the Distribution of Selection Coefficients for New Nonsynonymous Mutations Using Large Samples

The distribution of fitness effects (DFE) has considerable importance in population genetics. To date, estimates of the DFE come from studies using a small number of individuals. Thus, estimates of the proportion of moderately to strongly deleterious new mutations may be unreliable because such vari...

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Detalles Bibliográficos
Autores principales:	Kim, Bernard Y., Huber, Christian D., Lohmueller, Kirk E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Genetics Society of America 2017
Materias:	Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419480/ https://www.ncbi.nlm.nih.gov/pubmed/28249985 http://dx.doi.org/10.1534/genetics.116.197145

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