LSL-Kras(G12D); LSL-Trp53(R172H/+); Ink4(flox/+); Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer

Pancreatic cancer (PC) accumulates multiple genetic mutations, including activating KRAS mutations and inactivating TP53, SMAD4 and CDKN2A mutations, during progression. The combination of mutant KRAS with a single inactivating TP53, SMAD4 or CDKN2A mutation in genetically engineered mouse models (G...

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Detalles Bibliográficos
Autores principales: Ma, Lixiang, Saiyin, Hexige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419507/
https://www.ncbi.nlm.nih.gov/pubmed/28475592
http://dx.doi.org/10.1371/journal.pone.0176844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419507/
https://www.ncbi.nlm.nih.gov/pubmed/28475592
http://dx.doi.org/10.1371/journal.pone.0176844

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