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LSL-Kras(G12D); LSL-Trp53(R172H/+); Ink4(flox/+); Ptf1/p48-Cre mice are an applicable model for locally invasive and metastatic pancreatic cancer
Pancreatic cancer (PC) accumulates multiple genetic mutations, including activating KRAS mutations and inactivating TP53, SMAD4 and CDKN2A mutations, during progression. The combination of mutant KRAS with a single inactivating TP53, SMAD4 or CDKN2A mutation in genetically engineered mouse models (G...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419507/ https://www.ncbi.nlm.nih.gov/pubmed/28475592 http://dx.doi.org/10.1371/journal.pone.0176844 |