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Dioxins and related environmental contaminants increase TDP-43 levels

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative condition that is characterized by progressive loss of motor neurons and the accumulation of aggregated TAR DNA Binding Protein-43 (TDP-43, gene: TARDBP). Increasing evidence indicates that environmental factors cont...

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Detalles Bibliográficos
Autores principales: Ash, Peter E. A., Stanford, Elizabeth A., Al Abdulatif, Ali, Ramirez-Cardenas, Alejandra, Ballance, Heather I., Boudeau, Samantha, Jeh, Amanda, Murithi, James M., Tripodis, Yorghos, Murphy, George J., Sherr, David H., Wolozin, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420162/
https://www.ncbi.nlm.nih.gov/pubmed/28476168
http://dx.doi.org/10.1186/s13024-017-0177-9