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Parameter identifiability analysis and visualization in large-scale kinetic models of biosystems

BACKGROUND: Kinetic models of biochemical systems usually consist of ordinary differential equations that have many unknown parameters. Some of these parameters are often practically unidentifiable, that is, their values cannot be uniquely determined from the available data. Possible causes are lack...

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Detalles Bibliográficos
Autores principales: Gábor, Attila, Villaverde, Alejandro F., Banga, Julio R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5420165/
https://www.ncbi.nlm.nih.gov/pubmed/28476119
http://dx.doi.org/10.1186/s12918-017-0428-y