Candidate‐Gene Study of Functional Polymorphisms in SLCO1B1 and CYP3A4/5 and the Cholesterol‐Lowering Response to Simvastatin

Cholesterol‐lowering response to 40 mg simvastatin daily for 6 weeks was examined for associations with common genetic polymorphisms in key genes affecting simvastatin metabolism (CYP3A4 and CYP3A5) and transport (SLCO1B1). In white people (n = 608), SLCO1B1 521C was associated with lesser reduction...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitzmiller, JP, Luzum, JA, Dauki, A, Krauss, RM, Medina, MW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421731/
https://www.ncbi.nlm.nih.gov/pubmed/28482130
http://dx.doi.org/10.1111/cts.12432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421731/
https://www.ncbi.nlm.nih.gov/pubmed/28482130
http://dx.doi.org/10.1111/cts.12432

Ejemplares similares