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Early pathogenesis during infectious bursal disease in susceptible chickens is associated with changes in B cell genomic methylation and loss of genome integrity
We propose a model by which an increase in the genomic modification, 5-hydroxymethylcytosine (5hmC), contributes to B cell death within the chicken bursa of Fabricus (BF) infected with infectious bursal disease virus (IBDV). Our findings indicate that, following an IBDV infection, Rhode Island Red (...
Autores principales: | Ciccone, Nick A., Smith, Lorraine P., Mwangi, William, Boyd, Amy, Broadbent, Andrew J., Smith, Adrian L., Nair, Venugopal |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421744/ https://www.ncbi.nlm.nih.gov/pubmed/28322935 http://dx.doi.org/10.1016/j.dci.2017.03.014 |
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