PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses

The treatment of metastatic androgen-resistant prostate cancer remains a challenge. We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on t...

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Detalles Bibliográficos
Autores principales: Langut, Yael, Edinger, Nufar, Flashner-Abramson, Efrat, Melamed-Book, Naomi, Lebendiker, Mario, Levi-Kalisman, Yael, Klein, Shoshana, Levitzki, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421826/
https://www.ncbi.nlm.nih.gov/pubmed/28445962
http://dx.doi.org/10.18632/oncotarget.15733

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421826/
https://www.ncbi.nlm.nih.gov/pubmed/28445962
http://dx.doi.org/10.18632/oncotarget.15733

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