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PSMA-homing dsRNA chimeric protein vector kills prostate cancer cells and activates anti-tumor bystander responses

The treatment of metastatic androgen-resistant prostate cancer remains a challenge. We describe a protein vector that selectively delivers synthetic dsRNA, polyinosinic/polycytidylic acid (polyIC), to prostate tumors by targeting prostate specific membrane antigen (PSMA), which is overexpressed on t...

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Detalles Bibliográficos
Autores principales:	Langut, Yael, Edinger, Nufar, Flashner-Abramson, Efrat, Melamed-Book, Naomi, Lebendiker, Mario, Levi-Kalisman, Yael, Klein, Shoshana, Levitzki, Alexander
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421826/ https://www.ncbi.nlm.nih.gov/pubmed/28445962 http://dx.doi.org/10.18632/oncotarget.15733

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