Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging

Inhibition of thymidylate synthase (TS) results in a transient flare in DNA thymidine salvage pathway activity measurable with FLT ([(18)F]thymidine)-positron emission tomography (PET). Here we characterize this imaging strategy for potential clinical translation in non-small cell lung cancer (NSCLC...

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Detalles Bibliográficos
Autores principales: Chen, Xiao, Yang, Yizeng, Berger, Ian, Khalid, Urooj, Patel, Akash, Cai, Jenny, Farwell, Michael D., Langer, Corey, Aggarwal, Charu, Albelda, Steven M., Katz, Sharyn I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421841/
https://www.ncbi.nlm.nih.gov/pubmed/27655645
http://dx.doi.org/10.18632/oncotarget.12085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421841/
https://www.ncbi.nlm.nih.gov/pubmed/27655645
http://dx.doi.org/10.18632/oncotarget.12085

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