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Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging

Inhibition of thymidylate synthase (TS) results in a transient flare in DNA thymidine salvage pathway activity measurable with FLT ([(18)F]thymidine)-positron emission tomography (PET). Here we characterize this imaging strategy for potential clinical translation in non-small cell lung cancer (NSCLC...

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Detalles Bibliográficos
Autores principales:	Chen, Xiao, Yang, Yizeng, Berger, Ian, Khalid, Urooj, Patel, Akash, Cai, Jenny, Farwell, Michael D., Langer, Corey, Aggarwal, Charu, Albelda, Steven M., Katz, Sharyn I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421841/ https://www.ncbi.nlm.nih.gov/pubmed/27655645 http://dx.doi.org/10.18632/oncotarget.12085

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