High CFTR expression in philadelphia chromosome-positive acute leukemia protects and maintains continuous activation of BCR-ABL and related signaling pathways in combination with PP2A

Cystic fibrosis transmembrane conductance regulator (CFTR) is classified as an anion channel transporter of Cl(−) and HCO3(−). Through interactions with its PDZ domain, CFTR is capable of regulating other proteins, such as protein phosphatase 2A (PP2A). The aberrant expression and mutation of CFTR h...

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Detalles Bibliográficos
Autores principales: Yang, Xi, Yan, Tianyou, Gong, Yuping, Liu, Xuehua, Sun, Huaqin, Xu, Wenming, Wang, Chunsen, Naren, Duolan, Zheng, Yuhuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421860/
https://www.ncbi.nlm.nih.gov/pubmed/28445932
http://dx.doi.org/10.18632/oncotarget.15510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421860/
https://www.ncbi.nlm.nih.gov/pubmed/28445932
http://dx.doi.org/10.18632/oncotarget.15510

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