Cargando…

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells

Ewing sarcoma (EwS) is the second most common bone cancer in children and adolescents with a high metastatic potential. EwS development is driven by a specific chromosomal translocation resulting in the generation of a chimeric EWS-ETS transcription factor, most frequently EWS-FLI1. Nicotinamide ade...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mutz, Cornelia N., Schwentner, Raphaela, Aryee, Dave N.T., Bouchard, Eric D.J., Mejia, Edgard M., Hatch, Grant M., Kauer, Maximilian O., Katschnig, Anna M., Ban, Jozef, Garten, Antje, Alonso, Javier, Banerji, Versha, Kovar, Heinrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421879/ https://www.ncbi.nlm.nih.gov/pubmed/28160567 http://dx.doi.org/10.18632/oncotarget.14976

Ejemplares similares

The role of miR-17-92 in the miRegulatory landscape of Ewing sarcoma
por: Schwentner, Raphaela, et al.
Publicado: (2016)

EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma
por: Katschnig, A M, et al.
Publicado: (2017)

Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers
por: Tsafou, Kalliopi, et al.
Publicado: (2018)

EWS‐FLI1 impairs aryl hydrocarbon receptor activation by blocking tryptophan breakdown via the kynurenine pathway
por: Mutz, Cornelia N., et al.
Publicado: (2016)

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
por: Herrero-Martin, David, et al.
Publicado: (2011)

Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma
por: Niedan, S, et al.
Publicado: (2014)

YAP/TAZ inhibition reduces metastatic potential of Ewing sarcoma cells
por: Bierbaumer, Lisa, et al.
Publicado: (2021)

Variability in functional p53 reactivation by PRIMA-1(Met)/APR-246 in Ewing sarcoma
por: Aryee, D N T, et al.
Publicado: (2013)

EWS-FLI1 employs an E2F switch to drive target gene expression
por: Schwentner, Raphaela, et al.
Publicado: (2015)

Downstream EWS/FLI1 - upstream Ewing's sarcoma
por: Kovar, Heinrich
Publicado: (2010)

Oncogenic ETS fusions deregulate E2F3 target genes in Ewing sarcoma and prostate cancer
por: Bilke, Sven, et al.
Publicado: (2013)

Targeted Therapy for EWS-FLI1 in Ewing Sarcoma
por: Gong, Helong, et al.
Publicado: (2023)

Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma
por: Montoya, C., et al.
Publicado: (2020)

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma
por: Elzi, David J., et al.
Publicado: (2015)

Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
por: Javaheri, Tahereh, et al.
Publicado: (2016)

Zooming in on Long Non-Coding RNAs in Ewing Sarcoma Pathogenesis
por: Aryee, Dave N. T., et al.
Publicado: (2022)

Detection of EWS/FLI-1 fusion in non-Ewing soft tissue tumors
por: Trancău, IO, et al.
Publicado: (2015)

Detection of EWS/FLI-1 fusion in non-Ewing soft tissue tumors
por: Trancău, IO, et al.
Publicado: (2014)

A Molecular Function Map of Ewing's Sarcoma
por: Kauer, Maximilian, et al.
Publicado: (2009)

Mechanism and relevance of EWS/FLI-mediated transcriptional repression in Ewing sarcoma
por: Sankar, Savita, et al.
Publicado: (2012)

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
por: Cidre-Aranaz, Florencia, et al.
Publicado: (2015)

Chemosensitization of leukemia cells through inhibition of NAMPT
por: Gorski, Theresa, et al.
Publicado: (2014)

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma
por: Seong, Bo Kyung A., et al.
Publicado: (2021)

Variability of EWS chimaeric transcripts in Ewing tumours: a comparison of clinical and molecular data.
por: Zoubek, A., et al.
Publicado: (1994)

EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma
por: Fadul, John, et al.
Publicado: (2015)

A zebrafish transgenic model of Ewing’s sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis
por: Leacock, Stefanie W., et al.
Publicado: (2012)

EWS/ETS Regulates the Expression of the Dickkopf Family in Ewing Family Tumor Cells
por: Miyagawa, Yoshitaka, et al.
Publicado: (2009)

Targeting the EWS-ETS transcriptional program by BET bromodomain inhibition in Ewing sarcoma
por: Hensel, Tim, et al.
Publicado: (2015)

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth
por: Gierisch, Maria E., et al.
Publicado: (2019)

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma
por: Shi, Xianping, et al.
Publicado: (2020)

One oncogene, several vulnerabilities: EWS/FLI targeted therapies for Ewing sarcoma
por: Flores, Guillermo, et al.
Publicado: (2021)

Correction: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
por: Javaheri, Tahereh, et al.
Publicado: (2018)

Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity
por: Lynn, Heather, et al.
Publicado: (2023)

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma
por: Lu, Diana Y., et al.
Publicado: (2023)

Retraction Note: Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation
por: Javaheri, Tahereh, et al.
Publicado: (2019)

EWS-FLI1 low Ewing sarcoma cells demonstrate decreased susceptibility to T-cell-mediated tumor cell apoptosis
por: Bailey, Kelly M., et al.
Publicado: (2019)

GLI1 Is a Central Mediator of EWS/FLI1 Signaling in Ewing Tumors
por: Joo, Jay, et al.
Publicado: (2009)

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
por: Theisen, Emily R., et al.
Publicado: (2016)

Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish
por: Park, Hyewon, et al.
Publicado: (2016)

Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma
por: Stegmaier, Kimberly, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_85q3j1iipqkva568mi36f1bgs9