Specific up-regulation of p21 by a small active RNA sequence suppresses human colorectal cancer growth

The double stranded small active RNA (saRNA)- p21-saRNA-322 inhibits tumor growth by stimulating the p21 gene expression. We focused our research of p21-saRNA-322 on colorectal cancer because 1) p21 down-regulation is a signature abnormality of the cancer, and 2) colorectal cancer might be a suitabl...

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Detalles Bibliográficos
Autores principales: Wang, Lu-Lu, Guo, Hui-Hui, Zhan, Yun, Feng, Chen-Lin, Huang, Shuai, Han, Yan-Xing, Zheng, Wen-Sheng, Jiang, Jian-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421909/
https://www.ncbi.nlm.nih.gov/pubmed/28445988
http://dx.doi.org/10.18632/oncotarget.15918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421909/
https://www.ncbi.nlm.nih.gov/pubmed/28445988
http://dx.doi.org/10.18632/oncotarget.15918

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