Molecular docking, 3D-QSAR and structural optimization on imidazo-pyridine derivatives dually targeting AT1 and PPARγ

Telmisartan, a bifunctional agent of blood pressure lowering and glycemia reduction, was previously reported to antagonize angiotensin II type 1 (AT1) receptor and partially activate peroxisome proliferator-activated receptor γ (PPARγ) simultaneously. Through the modification to telmisartan, researc...

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Detalles Bibliográficos
Autores principales: Zhang, Jun, Hao, Qing-Qing, Liu, Xin, Jing, Zhi, Jia, Wen-Qing, Wang, Shu-Qing, Xu, Wei-Ren, Cheng, Xian-Chao, Wang, Run-Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421955/
https://www.ncbi.nlm.nih.gov/pubmed/28445965
http://dx.doi.org/10.18632/oncotarget.15778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5421955/
https://www.ncbi.nlm.nih.gov/pubmed/28445965
http://dx.doi.org/10.18632/oncotarget.15778

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