Celecoxib-mediated activation of endoplasmic reticulum stress induces de novo ceramide biosynthesis and apoptosis in hepatoma HepG2 cells

Ceramides are the major sphingolipid metabolites involved in cell survival and apoptosis. When HepG2 hepatoma cells were treated with celecoxib, the expression of the genes in de novo sphingolipid biosynthesis and sphingomyelinase pathway was upregulated and cellular ceramide was elevated. In additi...

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Detalles Bibliográficos
Autores principales: Maeng, Hyo Jin, Song, Jae-Hwi, Kim, Goon-Tae, Song, Yoo-Jeong, Lee, Kangpa, Kim, Jae-Young, Park, Tae-Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422027/
https://www.ncbi.nlm.nih.gov/pubmed/28193314
http://dx.doi.org/10.5483/BMBRep.2017.50.3.197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422027/
https://www.ncbi.nlm.nih.gov/pubmed/28193314
http://dx.doi.org/10.5483/BMBRep.2017.50.3.197

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