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The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can be increased and that the duration with which cohesin embraces DNA...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422210/ https://www.ncbi.nlm.nih.gov/pubmed/28475897 http://dx.doi.org/10.1016/j.cell.2017.04.013 |