Pri-microRNA-124 rs531564 polymorphism minor allele increases the risk of pulmonary artery hypertension by abnormally enhancing proliferation of pulmonary artery smooth muscle cells

MicroRNA-124 (miR-124) has been reported to be downregulated in the cells exposed to hypoxia, which was confirmed in our study. We then used online microRNA target prediction tools to identify GRB2, SMAD5, and JAG1 as the candidate target genes of miR-124, and we next validated GRB2 as a direct gene...

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Detalles Bibliográficos
Autores principales: Li, Quanzhong, Qian, Zongjie, Wang, Linqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422315/
https://www.ncbi.nlm.nih.gov/pubmed/28496318
http://dx.doi.org/10.2147/COPD.S99318

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422315/
https://www.ncbi.nlm.nih.gov/pubmed/28496318
http://dx.doi.org/10.2147/COPD.S99318

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