Activation of Sirt1/FXR Signaling Pathway Attenuates Triptolide-Induced Hepatotoxicity in Rats

Triptolide (TP), a diterpenoid isolated from Tripterygium wilfordii Hook F, has an excellent pharmacological profile of immunosuppression and anti-tumor activities, but its clinical applications are severely restricted due to its severe and cumulative toxicities. The farnesoid X receptor (FXR) is th...

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Detalles Bibliográficos
Autores principales: Yang, Jing, Sun, Lixin, Wang, Lu, Hassan, Hozeifa M., Wang, Xuan, Hylemon, Phillip B., Wang, Tao, Zhou, Huiping, Zhang, Luyong, Jiang, Zhenzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422577/
https://www.ncbi.nlm.nih.gov/pubmed/28536529
http://dx.doi.org/10.3389/fphar.2017.00260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422577/
https://www.ncbi.nlm.nih.gov/pubmed/28536529
http://dx.doi.org/10.3389/fphar.2017.00260

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