A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis

CD40, a member of the tumour necrosis factor receptor (TNFR) superfamily, has the capacity to cause extensive apoptosis in carcinoma cells, while sparing normal epithelial cells. Yet, apoptosis is only achieved by membrane-presented CD40 ligand (mCD40L), as soluble receptor agonists are but weakly p...

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Detalles Bibliográficos
Autores principales: Dunnill, C J, Ibraheem, K, Mohamed, A, Southgate, J, Georgopoulos, N T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422712/
https://www.ncbi.nlm.nih.gov/pubmed/27869172
http://dx.doi.org/10.1038/onc.2016.401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422712/
https://www.ncbi.nlm.nih.gov/pubmed/27869172
http://dx.doi.org/10.1038/onc.2016.401

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