Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo

BACKGROUND: Mitochondrial dysfunction has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Functional studies of mitochondrial bioenergetics have focused mostly on superoxide dismutase 1 (SOD1) mutants, and showed that mutant human...

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Detalles Bibliográficos
Autores principales: Kawamata, Hibiki, Peixoto, Pablo, Konrad, Csaba, Palomo, Gloria, Bredvik, Kirsten, Gerges, Meri, Valsecchi, Federica, Petrucelli, Leonard, Ravits, John M., Starkov, Anatoly, Manfredi, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422931/
https://www.ncbi.nlm.nih.gov/pubmed/28482850
http://dx.doi.org/10.1186/s13024-017-0180-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422931/
https://www.ncbi.nlm.nih.gov/pubmed/28482850
http://dx.doi.org/10.1186/s13024-017-0180-1

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