The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

BACKGROUND: Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that recombinant human PRG4 (rhPRG4) is a putative ligand for CD44 receptor. rhPRG4-CD44 interaction inhibits cytokine-induced rheumatoid arth...

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Detalles Bibliográficos
Autores principales: Alquraini, Ali, Jamal, Maha, Zhang, Ling, Schmidt, Tannin, Jay, Gregory D., Elsaid, Khaled A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423025/
https://www.ncbi.nlm.nih.gov/pubmed/28482921
http://dx.doi.org/10.1186/s13075-017-1301-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423025/
https://www.ncbi.nlm.nih.gov/pubmed/28482921
http://dx.doi.org/10.1186/s13075-017-1301-5

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