Introducing COCOS: codon consequence scanner for annotating reading frame changes induced by stop-lost and frame shift variants

SUMMARY: Reading frame altering genomic variants can impact gene expression levels and the structure of protein products, thus potentially inducing disease phenotypes. Current annotation approaches report the impact of such variants in the context of altered DNA sequence only; attributes of the resu...

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Detalles Bibliográficos
Autores principales: Butkiewicz, Mariusz, Haines, Jonathan L, Bush, William S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Applications Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423451/
https://www.ncbi.nlm.nih.gov/pubmed/28122779
http://dx.doi.org/10.1093/bioinformatics/btw820

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423451/
https://www.ncbi.nlm.nih.gov/pubmed/28122779
http://dx.doi.org/10.1093/bioinformatics/btw820

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