Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1

Humans are unable to synthesise ascorbate (Vitamin C) due to the lack of a functional gulonolactone oxidase (Gulo), the enzyme that catalyses the final step in the biosynthesis pathway. Ascorbate is a vital micronutrient required for many biological functions, including as a cofactor for metalloenzy...

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Detalles Bibliográficos
Autores principales: Flett, Teresa, Campbell, Elizabeth J., Phillips, Elisabeth, Vissers, Margreet C. M., Dachs, Gabi U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423483/
https://www.ncbi.nlm.nih.gov/pubmed/28548062
http://dx.doi.org/10.3390/biomedicines2010098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423483/
https://www.ncbi.nlm.nih.gov/pubmed/28548062
http://dx.doi.org/10.3390/biomedicines2010098

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