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Measures of RNA metabolism rates: Toward a definition at the level of single bonds

We give an overview of experimental and computational methods to estimate RNA metabolism rates genome-wide. We then advocate a local definition of RNA metabolism rate at the level of individual phosphodiester bonds. Rates of formation and disappearance of individual bonds are unambiguously defined,...

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Detalles Bibliográficos
Autores principales: Wachutka, Leonhard, Gagneur, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423486/
https://www.ncbi.nlm.nih.gov/pubmed/27841720
http://dx.doi.org/10.1080/21541264.2016.1257972