DNA Polymerase ɛ Deficiency Leading to an Ultramutator Phenotype: A Novel Clinically Relevant Entity

Deficiencies in DNA repair due to mutations in the exonuclease domain of DNA polymerase ɛ have recently been described in a subset of cancers characterized by an ultramutated and microsatellite stable (MSS) phenotype. This alteration in DNA repair is distinct from the better‐known mismatch repair de...

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Detalles Bibliográficos
Autores principales: Castellucci, Enrico, He, Tianfang, Goldstein, D. Yitzchak, Halmos, Balazs, Chuy, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AlphaMed Press 2017
Materias:
Precision Medicine Clinic
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423519/
https://www.ncbi.nlm.nih.gov/pubmed/28465371
http://dx.doi.org/10.1634/theoncologist.2017-0034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423519/
https://www.ncbi.nlm.nih.gov/pubmed/28465371
http://dx.doi.org/10.1634/theoncologist.2017-0034

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