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Structure of a AAA+ unfoldase in the process of unfolding substrate

AAA+ unfoldases are thought to unfold substrate through the central pore of their hexameric structures, but how this process occurs is not known. VAT, the Thermoplasma acidophilum homologue of eukaryotic CDC48/p97, works in conjunction with the proteasome to degrade misfolded or damaged proteins. We...

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Detalles Bibliográficos
Autores principales: Ripstein, Zev A, Huang, Rui, Augustyniak, Rafal, Kay, Lewis E, Rubinstein, John L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423775/
https://www.ncbi.nlm.nih.gov/pubmed/28390173
http://dx.doi.org/10.7554/eLife.25754