A single-layer platform for Boolean logic and arithmetic through DNA excision in mammalian cells

Genetic circuits engineered for mammalian cells often require extensive fine-tuning to perform their intended functions. To overcome this problem, we present a generalizable biocomputing platform that can engineer genetic circuits which function in human cells with minimal optimization. We used our...

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Detalles Bibliográficos
Autores principales: Weinberg, Benjamin H., Hang Pham, N. T., Caraballo, Leidy D., Lozanoski, Thomas, Engel, Adrien, Bhatia, Swapnil, Wong, Wilson W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423837/
https://www.ncbi.nlm.nih.gov/pubmed/28346402
http://dx.doi.org/10.1038/nbt.3805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423837/
https://www.ncbi.nlm.nih.gov/pubmed/28346402
http://dx.doi.org/10.1038/nbt.3805

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