Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state

Plasmacytoid dendritic cells (pDCs) detect viruses initiating antiviral IFN-I responses. The microbiota is known to shape immune responses, but whether it influences pDC homeostasis and/or function is poorly understood. By comparing pDCs in germ-free and specific pathogen-free mice, we found that th...

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Detalles Bibliográficos
Autores principales: Swiecki, Melissa, Miller, Hannah, Sesti-Costa, Renata, Cella, Marina, Gilfillan, Susan, Colonna, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423869/
https://www.ncbi.nlm.nih.gov/pubmed/27827374
http://dx.doi.org/10.1038/mi.2016.99

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423869/
https://www.ncbi.nlm.nih.gov/pubmed/27827374
http://dx.doi.org/10.1038/mi.2016.99

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