Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice

AIMS/HYPOTHESIS: Transcription factor 7-like 2 (TCF7L2) is a high mobility group (HMG) box-containing transcription factor and downstream effector of the Wnt signalling pathway. SNPs in the TCF7L2 gene have previously been associated with an increased risk of type 2 diabetes in genome-wide associati...

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Detalles Bibliográficos
Autores principales: da Silva Xavier, Gabriela, Mondragon, Angeles, Mourougavelou, Vishnou, Cruciani-Guglielmacci, Céline, Denom, Jessica, Herrera, Pedro Luis, Magnan, Christophe, Rutter, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423960/
https://www.ncbi.nlm.nih.gov/pubmed/28343277
http://dx.doi.org/10.1007/s00125-017-4242-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423960/
https://www.ncbi.nlm.nih.gov/pubmed/28343277
http://dx.doi.org/10.1007/s00125-017-4242-2

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