Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia

Neem leaf extract (NLE) has medicinal properties, which have been attributed to its limonoid content. We identified the NLE tetranorterpenoid, nimbolide, as being the key limonoid responsible for the cytotoxicity of NLE in various preclinical models of human B-lymphocyte cancer. Of the models tested...

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Detalles Bibliográficos
Autores principales: Chitta, K, Paulus, A, Caulfield, T R, Akhtar, S, Blake, M-KK, Ailawadhi, S, Knight, J, Heckman, M G, Pinkerton, A, Chanan-Khan, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424099/
https://www.ncbi.nlm.nih.gov/pubmed/25382610
http://dx.doi.org/10.1038/bcj.2014.74

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424099/
https://www.ncbi.nlm.nih.gov/pubmed/25382610
http://dx.doi.org/10.1038/bcj.2014.74

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