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Nimbolide targets BCL2 and induces apoptosis in preclinical models of Waldenströms macroglobulinemia
Neem leaf extract (NLE) has medicinal properties, which have been attributed to its limonoid content. We identified the NLE tetranorterpenoid, nimbolide, as being the key limonoid responsible for the cytotoxicity of NLE in various preclinical models of human B-lymphocyte cancer. Of the models tested...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424099/ https://www.ncbi.nlm.nih.gov/pubmed/25382610 http://dx.doi.org/10.1038/bcj.2014.74 |