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Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death

Hereditary pancreatitis (HP) is an autosomal dominant disease that displays the features of both acute and chronic pancreatitis. Mutations in human cationic trypsinogen (PRSS1) are associated with HP and have provided some insight into the pathogenesis of pancreatitis, but mechanisms responsible for...

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Detalles Bibliográficos
Autores principales: Athwal, T, Huang, W, Mukherjee, R, Latawiec, D, Chvanov, M, Clarke, R, Smith, K, Campbell, F, Merriman, C, Criddle, D, Sutton, R, Neoptolemos, J, Vlatković, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424103/
https://www.ncbi.nlm.nih.gov/pubmed/24722290
http://dx.doi.org/10.1038/cddis.2014.120