CGP37157, an inhibitor of the mitochondrial Na(+)/Ca(2+) exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca(2+) channels

Inhibition of the mitochondrial Na(+)/Ca(2+) exchanger (NCLX) by CGP37157 is protective in models of neuronal injury that involve disruption of intracellular Ca(2+) homeostasis. However, the Ca(2+) signaling pathways and stores underlying neuroprotection by that inhibitor are not well defined. In th...

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Detalles Bibliográficos
Autores principales: Ruiz, A, Alberdi, E, Matute, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424111/
https://www.ncbi.nlm.nih.gov/pubmed/24722281
http://dx.doi.org/10.1038/cddis.2014.134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424111/
https://www.ncbi.nlm.nih.gov/pubmed/24722281
http://dx.doi.org/10.1038/cddis.2014.134

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