Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response

Betulinic acid (BetA) is a plant-derived pentacyclic triterpenoid that exerts potent anti-cancer effects in vitro and in vivo. It was shown to induce apoptosis via a direct effect on mitochondria. This is largely independent of proapoptotic BAK and BAX, but can be inhibited by cyclosporin A (CsA), a...

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Detalles Bibliográficos
Autores principales: Potze, L, Mullauer, F B, Colak, S, Kessler, J H, Medema, J P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424116/
https://www.ncbi.nlm.nih.gov/pubmed/24722294
http://dx.doi.org/10.1038/cddis.2014.139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424116/
https://www.ncbi.nlm.nih.gov/pubmed/24722294
http://dx.doi.org/10.1038/cddis.2014.139

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