Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy

Gene deletion-induced autophagy deficiency leads to neural tube defects (NTDs), similar to those in diabetic pregnancy. Here we report the key autophagy regulators modulated by diabetes in the murine developing neuroepithelium. Diabetes predominantly leads to exencephaly, induces neuroepithelial cel...

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Detalles Bibliográficos
Autores principales: Wang, Fang, Xu, Cheng, Reece, E. Albert, Li, Xuezheng, Wu, Yanqing, Harman, Christopher, Yu, Jingwen, Dong, Daoyin, Wang, Cheng, Yang, Penghua, Zhong, Jianxiang, Yang, Peixin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424165/
https://www.ncbi.nlm.nih.gov/pubmed/28474670
http://dx.doi.org/10.1038/ncomms15182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424165/
https://www.ncbi.nlm.nih.gov/pubmed/28474670
http://dx.doi.org/10.1038/ncomms15182

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