Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome

An unorthodox, surprising mechanism of resistance to the antibiotic linezolid was revealed by cryo-electron microscopy (cryo-EM) in the 70S ribosomes from a clinical isolate of Staphylococcus aureus. This high-resolution structural information demonstrated that a single amino acid deletion in riboso...

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Detalles Bibliográficos
Autores principales: Belousoff, Matthew J., Eyal, Zohar, Radjainia, Mazdak, Ahmed, Tofayel, Bamert, Rebecca S., Matzov, Donna, Bashan, Anat, Zimmerman, Ella, Mishra, Satabdi, Cameron, David, Elmlund, Hans, Peleg, Anton Y., Bhushan, Shashi, Lithgow, Trevor, Yonath, Ada
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424203/
https://www.ncbi.nlm.nih.gov/pubmed/28487427
http://dx.doi.org/10.1128/mBio.00395-17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424203/
https://www.ncbi.nlm.nih.gov/pubmed/28487427
http://dx.doi.org/10.1128/mBio.00395-17

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